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However, our cox proportional hazards models did account for the approximate duration of digoxin therapy by defining digoxin use as a time-dependent covariate based on whether the patient was on digoxin at each follow-up visit.

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8 months placebo-controlled mortality morbidity study of norvasc 5-10 mg in 1153 patients with nyha classes iii n 931 or iv n 222 heart failure on stable doses of diuretics, digoxin, and ace inhibitors, norvasc had no effect on the primary endpoint of the study which was the combined endpoint of all-cause mortality and cardiac morbidity as defined by life-threatening arrhythmia, acute myocardial infarction, or hospitalization for worsened heart failure , or on nyha classification, or symptoms of heart failure.

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