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Vytorin contains ezetimibe and simvastatin, two lipid-lowering compounds with complementary mechanisms of action.

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Ezetimibe and simvastatin can cause the breakdown of muscle tissuewhich can lead to kidney failureThis happens more often in womenin older adultsor in people who have kidney disease or poorly controlled hypothyroidismunderactive thyroid

Simvastatin is in a group of drugs called HMG CoA reductase inhibitorsorstatins

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

Abdominal or stomach fullness bloating chills constipation darkened urine fast heartbeat fever hives hoarseness indigestion itching joint pain largehive-like swelling on the faceeyelidslipstonguethroathandslegsfeetor sex organs loss of appetite nausea pains in the stomachsideor abdomenpossibly radiating to the back rash redness of the skin shortness of breath stiffness swelling of the eyelidsfacelipshandsor feet tightness in the chest trouble breathing or swallowing vomiting yellow eyes or skin.

Prescribing recommendations for interacting agents are summarized in Table 1see also DOSAGE AND ADMINISTRATIONDRUG INTERACTIONSand CLINICAL PHARMACOLOGY

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vytorin 10 20 was significantly more effective than doubling the dose of simvastatin to 40 mg.

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